49ers to face Packers without starting QB Brock Purdy and DE Nick Bosa.

Why it matters: The absence of Purdy and Bosa creates significant challenges for the 49ers in a crucial matchup that could impact their postseason hopes.

• Purdy's shoulder soreness and Bosa's hip/oblique injury will require backup players to step up in their absence.
• The team will rely on veteran Brandon Allen as the starting quarterback, with Josh Dobbs as the backup.
• Left tackle Trent Williams is listed as questionable with an ankle injury, adding further uncertainty to the offensive line.

What's new: The unexpected absence of Purdy raises concerns about the severity of his shoulder soreness and the timeline for his return.

• Purdy underwent an MRI that showed no structural damage, but his availability for future games remains uncertain.
• Allen, a sixth-round pick, will have an opportunity to showcase his skills as he takes over the starting role in Purdy's absence.

Yes, but: Despite the challenges posed by the injuries, Coach Kyle Shanahan remains optimistic and believes the team has a chance to win.

• The 49ers have other talented players who can step up and contribute in the absence of Purdy and Bosa.
• The team's fighting spirit and determination will be crucial in overcoming these setbacks.

What to watch: The performance of the backup players, including Allen and the defensive replacements for Bosa, will be closely monitored during the game against the Packers.

• How well the offensive line protects Allen and creates opportunities for the running game will be key factors in the team's success.
• The defense must compensate for Bosa's absence by generating pressure on the Packers' quarterback and limiting their offensive production.

What's next: The 49ers will continue to assess the health status of Trent Williams and make a decision on his availability closer to kickoff.

• The team will also monitor Purdy's progress and determine the next steps in his recovery.
• The focus remains on securing a victory against the Packers to boost their playoff chances.

The bottom line: The injuries to Purdy and Bosa present significant challenges for the 49ers, but they remain determined to fight and overcome these obstacles.

• The performance of backup players and the ability of the coaching staff to strategize effectively will be crucial in achieving success.
• Ultimately, the outcome of the game against the Packers will have a substantial impact on the 49ers' postseason aspirations.

49ers to face Packers without starting QB Brock Purdy and DE Nick Bosa.

Why it matters: The absence of Purdy and Bosa creates significant challenges for the 49ers in a crucial matchup that could impact their postseason hopes.

• Purdy's shoulder soreness and Bosa's hip/oblique injury will require backup players to step up in their absence.
• The team will rely on veteran Brandon Allen as the starting quarterback, with Josh Dobbs as the backup.
• Left tackle Trent Williams is listed as questionable with an ankle injury, adding further uncertainty to the offensive line.

What's new: The unexpected absence of Purdy raises concerns about the severity of his shoulder soreness and the timeline for his return.

• Purdy underwent an MRI that showed no structural damage, but his availability for future games remains uncertain.
• Allen, a sixth-round pick, will have an opportunity to showcase his skills as he takes over the starting role in Purdy's absence.

Yes, but: Despite the challenges posed by the injuries, Coach Kyle Shanahan remains optimistic and believes the team has a chance to win.

• The 49ers have other talented players who can step up and contribute in the absence of Purdy and Bosa.
• The team's fighting spirit and determination will be crucial in overcoming these setbacks.

What to watch: The performance of the backup players, including Allen and the defensive replacements for Bosa, will be closely monitored during the game against the Packers.

• How well the offensive line protects Allen and creates opportunities for the running game will be key factors in the team's success.
• The defense must compensate for Bosa's absence by generating pressure on the Packers' quarterback and limiting their offensive production.

What's next: The 49ers will continue to assess the health status of Trent Williams and make a decision on his availability closer to kickoff.

• The team will also monitor Purdy's progress and determine the next steps in his recovery.
• The focus remains on securing a victory against the Packers to boost their playoff chances.

The bottom line: The injuries to Purdy and Bosa present significant challenges for the 49ers, but they remain determined to fight and overcome these obstacles.

• The performance of backup players and the ability of the coaching staff to strategize effectively will be crucial in achieving success.
• Ultimately, the outcome of the game against the Packers will have a substantial impact on the 49ers' postseason aspirations.