The Los Angeles Chargers face significant challenges as they prepare for their game against the Kansas City Chiefs, with multiple key players ruled out or listed as questionable.

Why it matters: The absence of key players, including star linebacker Joey Bosa and offensive tackle Rashawn Slater, could significantly impact the Chargers' performance against the undefeated Chiefs.

• Bosa's absence due to a hip injury deprives the Chargers of one of their top defensive playmakers.
• The absence of Rashawn Slater further weakens the offensive line's ability to protect quarterback Justin Herbert.

Yes, but: Despite the injuries, there is some positive news on the injury front. Quarterback Justin Herbert, who aggravated an ankle sprain in Week 3, expressed his determination to play and has shown improvement during practice.

• Herbert's presence on the field gives the Chargers a fighting chance against the Chiefs' formidable defense.

What to watch: The Chargers will need other players to step up in the absence of key contributors. It will be crucial to monitor how the team adjusts its strategies and game plans to compensate for the injured players.

• Receivers like Joshua Palmer may have an opportunity to shine in the absence of Derius Davis, who is listed as questionable with a hamstring injury.

The bottom line: Despite the challenges posed by the lengthy injury report, Chargers coach Jim Harbaugh remains confident in the team's ability to rise to the occasion.

• Harbaugh emphasized that this presents an opportunity for other players to step up, demonstrate strength and toughness, and make significant contributions in the divisional matchup against the Chiefs.

Our thought bubble: The Chargers' ability to adapt and overcome adversity will be tested in this crucial game. Their success will depend on the collective effort of the remaining roster and the coaching staff's ability to strategize effectively.

• This game provides a chance for lesser-known players to make a name for themselves and prove their value to the team.

What's next: As the game unfolds, it will be intriguing to see which players rise to the occasion and how the Chargers' adjustments impact their performance against the Chiefs.

• The outcome of this game could have significant implications for the Chargers' season and their standing in the competitive AFC West division.

The Los Angeles Chargers face significant challenges as they prepare for their game against the Kansas City Chiefs, with multiple key players ruled out or listed as questionable.

Why it matters: The absence of key players, including star linebacker Joey Bosa and offensive tackle Rashawn Slater, could significantly impact the Chargers' performance against the undefeated Chiefs.

• Bosa's absence due to a hip injury deprives the Chargers of one of their top defensive playmakers.
• The absence of Rashawn Slater further weakens the offensive line's ability to protect quarterback Justin Herbert.

Yes, but: Despite the injuries, there is some positive news on the injury front. Quarterback Justin Herbert, who aggravated an ankle sprain in Week 3, expressed his determination to play and has shown improvement during practice.

• Herbert's presence on the field gives the Chargers a fighting chance against the Chiefs' formidable defense.

What to watch: The Chargers will need other players to step up in the absence of key contributors. It will be crucial to monitor how the team adjusts its strategies and game plans to compensate for the injured players.

• Receivers like Joshua Palmer may have an opportunity to shine in the absence of Derius Davis, who is listed as questionable with a hamstring injury.

The bottom line: Despite the challenges posed by the lengthy injury report, Chargers coach Jim Harbaugh remains confident in the team's ability to rise to the occasion.

• Harbaugh emphasized that this presents an opportunity for other players to step up, demonstrate strength and toughness, and make significant contributions in the divisional matchup against the Chiefs.

Our thought bubble: The Chargers' ability to adapt and overcome adversity will be tested in this crucial game. Their success will depend on the collective effort of the remaining roster and the coaching staff's ability to strategize effectively.

• This game provides a chance for lesser-known players to make a name for themselves and prove their value to the team.

What's next: As the game unfolds, it will be intriguing to see which players rise to the occasion and how the Chargers' adjustments impact their performance against the Chiefs.

• The outcome of this game could have significant implications for the Chargers' season and their standing in the competitive AFC West division.