Isaac Guerendo plans to play despite a sprained foot, but other key players for the 49ers are listed as questionable or ruled out for the game against the Rams.

Why it matters: Guerendo's determination to play through injury highlights his commitment to the team and his desire to contribute to their success.

• The 49ers are facing a crucial divisional matchup against the Rams, and having Guerendo available would provide a boost to their running game.

What's new: Guerendo, who assumed the starting role due to injuries to other running backs, had an impressive performance in his first start before getting injured.

• He rushed for 78 yards and two touchdowns against the Bears, showcasing his potential as a dynamic playmaker.

Yes, but: Despite his optimism, Guerendo's limited practice participation raises concerns about his ability to perform at full capacity.

• If Guerendo is unable to handle a full workload, Patrick Taylor Jr. will likely see increased playing time in the backfield.

What to watch: Keep an eye on Guerendo's pre-game warm-up and any updates from the team regarding his status.

• The decision to play him will depend on his ability to manage the pain and perform effectively.

What's next: The outcome of this game could have implications for the 49ers' playoff hopes and their positioning within the highly competitive NFC West division.

• It remains to be seen how Guerendo's injury will impact the team's overall game plan and offensive strategy.

The bottom line: Guerendo's determination to play through injury demonstrates his dedication to the team and his willingness to contribute, but the 49ers must also consider his long-term health and the effectiveness of their running game.

Isaac Guerendo plans to play despite a sprained foot, but other key players for the 49ers are listed as questionable or ruled out for the game against the Rams.

Why it matters: Guerendo's determination to play through injury highlights his commitment to the team and his desire to contribute to their success.

• The 49ers are facing a crucial divisional matchup against the Rams, and having Guerendo available would provide a boost to their running game.

What's new: Guerendo, who assumed the starting role due to injuries to other running backs, had an impressive performance in his first start before getting injured.

• He rushed for 78 yards and two touchdowns against the Bears, showcasing his potential as a dynamic playmaker.

Yes, but: Despite his optimism, Guerendo's limited practice participation raises concerns about his ability to perform at full capacity.

• If Guerendo is unable to handle a full workload, Patrick Taylor Jr. will likely see increased playing time in the backfield.

What to watch: Keep an eye on Guerendo's pre-game warm-up and any updates from the team regarding his status.

• The decision to play him will depend on his ability to manage the pain and perform effectively.

What's next: The outcome of this game could have implications for the 49ers' playoff hopes and their positioning within the highly competitive NFC West division.

• It remains to be seen how Guerendo's injury will impact the team's overall game plan and offensive strategy.

The bottom line: Guerendo's determination to play through injury demonstrates his dedication to the team and his willingness to contribute, but the 49ers must also consider his long-term health and the effectiveness of their running game.