Steelers RB Cordarrelle Patterson ruled out with ankle injury during game against Colts.

Why it matters: Patterson's absence leaves a void in the Steelers' offense and puts more pressure on other running backs to step up.

What's new: Patterson suffered the ankle injury in the second quarter after a 10-yard gain that resulted in a first down. The Steelers turned the ball over on the following play.

Yes, but: Patterson had been performing well prior to the injury, averaging 7.2 yards per carry and making an impact in both rushing and receiving.

• He had six carries for 43 yards and two catches for 19 yards before exiting the game.

What to watch: The Steelers will now rely heavily on Najee Harris and practice squad running back Aaron Shampklin to fill the void left by Patterson's absence.

• Harris struggled early in the third quarter, gaining only 8 yards on eight carries.
• Shampklin had a limited role, with one carry for a 5-yard gain before halftime.

What's next: The team will need to assess the severity of Patterson's ankle injury and determine the expected recovery timeline.

• They may explore options to add depth at the running back position if Patterson's absence is prolonged.

The bottom line: Patterson's injury is a setback for the Steelers' offense, requiring other players to step up and fill his role in the running game.