Shanahan on Kittle's return: "Kittle will return to practice this week."

The San Francisco 49ers face significant challenges as linebacker Fred Warner is lost for the season due to a serious ankle injury, while tight end George Kittle prepares to return to practice.

Why it matters: Warner's absence will be felt deeply on the field, where he has been a cornerstone of the 49ers' defense.

• As a leader on the defense and a key player in their 3-4 scheme, Warner’s loss complicates the 49ers' ability to contain opposing offenses.
• The team will need to rely on younger players to step up at the linebacker position, which may impact their overall defensive effectiveness.

What’s new: Kittle’s return to practice provides a glimmer of hope for a struggling offense.

• After being sidelined since Week 2 due to a hamstring strain, Kittle opens a 21-day window to return before the Falcons matchup.
• His presence could bolster the passing game significantly, offering quarterback Brock Purdy a reliable target in critical situations.

Yes, but: While Kittle's potential return is encouraging, his effectiveness remains uncertain after a lengthy injury layoff.

• Coach Kyle Shanahan emphasized that Kittle will participate in practice this week, yet it remains to be seen if he can regain his pre-injury form.
• An effective Kittle can make a difference, particularly against a Falcons team that struggles defensively.

What to watch: The health of Purdy and rookie receiver Ricky Pearsall will be crucial in the coming games.

• Purdy, who has been dealing with a toe injury, has missed two games, raising questions about his readiness to lead the offense effectively.
• Pearsall, nursing a right knee injury from last week’s game, adds additional uncertainty to the receiving corps.

The bottom line: The 49ers are at a crossroads, facing injury challenges that could shape their season moving forward.

• With Warner out for the year and key offensive pieces returning from injuries, the team must quickly adapt if they hope to remain competitive.
• The upcoming matchup against the Atlanta Falcons will serve as a litmus test for how well they can navigate these changes and capitalize on the return of Kittle.

As the 49ers prepare for this critical juncture in their season, all eyes will be on practice reports and player availability leading up to their next game.